이미지 제공: Stanislav Kondratiev

Publications

Publications

  1. D. Maiti, H. Yu, B. S. Kim, M. Naito, S. Yamashita, H. J. Kim*, K. Miyata* "Rose bengal decorated NaYF4:Tb nanoparticles for low dose X-ray induced photodynamic therapy in cancer cells, in submission (2022). *corresponding authors.

  2. H. J. Kim, S. K. Seo, H. Y. Park "Physical and chemical advances of synthetic delivery vehicles to enhance mRNA vaccine efficacy" Journal of Controlled Release, 345, 405-416 (2022).

  3. J. Yum, B. S. Kim, S. Ogura, R. Kamegawa, M. Naito, Y. Yamasaki, H. J. Kim*, K. Miyata* "Fine-tuning of polyaspartamide derivatives with alicyclic moieties for systemic mRNA delivery" Journal of Controlled Release, 342, 148-156 (2022). *corresponding authors.

  4. H. J. Kim, A. Kim, K. Miyata "Synthetic molecules libraries for nucleic acid delivery: design parameters in cationic/ionizable lipids and polymers" Drug Matabolism and Pharmacokinetics, 42, 100428 (2022).

  5. R. Kamegawa, M. Naito, S. Uchida, H. J. Kim, B. S. Kim, K. Miyata "Bioinspired silicification of mRNA-loaded polyion complexes for macrophage-targeted mRNA delivery" ACS Applied Bio Materials, 4, 7790-7799 (2021).

  6. J. Y. Kim, J. Y. Lee, H. Y. Park, H. Kim. J. H. Dang  H. J. Kim, W. J. Jeong “Combination of peptides with biological, organic,  and inorganic materials for synergistically enhanced diagnostics and therapeuticsPeptide Science, in press (2021).

  7. B. S. Kim, M. Naito, H. Chaya, M. Hori, K. Hayashi, H. S. Min, Y. Yi, H. J. Kim, T. Nagata, Y. Anraku, A. Kishimura, K. Kataoka, K. Miyata “Noncovalent stabilization of vesicular polyion complexes with chemically modified/single-stranded oligonucleotides and PEG-b-guanidinylated polypeptides for intracavity encapsulation of effector enzymes aimed at cooperative gene knockdown” Biomacromolecules 21, 4365-4376 (2020).

  8. B. S. Kim, M. Naito, R. Kamegawa, H. J. Kim, R. Iizuka, T. Funatsu, S. Ueno, T. Ichiki, A. Kishimura, K. Miyata “Photo-reactive oligodeoxynucleotide-embedded nanovesicles (PROsomes) with switchable stability for efficient cellular uptake and gene knockdown” Chemical Communications 56, 9477-9480 (2020).

  9. H. S. Min*, H. J. Kim*, M. Naito, S. Ogura, K. Toh, K. Hayashi, B. S. Kim, S. Fukushima, Y. Anraku, K. Miyata, K. Kataoka “Systemic Brain Delivery of Antisense Oligonucleotides across the Brain-Brain Barrier with a Glucose-Coated Polymeric Nanocarrier” Angew. Chem. Int. Ed. 59, 8173-8180 (2020). *co-first author.

  10. B. S. Kim, S. Osawa, M. Naito, S. Ogura, R. Kamegawa, H. Ishida, H. J. Kim, S. Uchida, K. Miyata “A 50-nm-sized micellar assembly of thermoresponsive polymer-antisense oligonucleotide conjugates for enhanced gene knockdown in lung cancer by intratracheal administrationAdvanced Therapeutics 3, 1900123 (2020).

  11. H. J. Kim*, S. Ogura, T. Otabe, R. Kamegawa, M. Sato, K. Kataoka, K. Miyata*, “Fine-Tuning of Hydrophobicity in Amphiphilic Polyaspartamide Derivatives for Rapid and Transient Expression of Messenger RNA Directed Toward Genome Engineering in Brain” ACS Central Science 5, 1866-1875 (2019). *corresponding author.

  12. B. S. Kim*, H. J. Kim*, S. Osawa, K. Hayashi, K. Toh, M. Naito, H. S. Min, Y. Yi, I. C. Kwon, K. Kataoka, K. Miyata “Dually Stabilized Triblock Copolymer Micelles with Hydrophilic Shell and Hydrophobic Interlayer for Systemic Antisense Oligonucleotide Delivery to Solid TumorACS Biomaterials Science & Engineering 5, 5770-5780 (2019). *co-first author.

  13. S. Watanabe*, K. Hayashi*, K. Toh*, H. J. Kim*, X. Liu, H. Chaya, S. Fukushima, K. Katsushima, Y. Kondo, S. Uchida, S. Ogura, T. Nomoto, H. Takemoto, H. Cabral, H. Kinoh, H. Y. Tanaka, M. R. Kano, Y. Matsumoto, H. Fukuhara, S. Uchida, M. Nangaku, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, “In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancersNature Communications 10, 1894 (2019) *co-first author.

  14. B. S. Kim, S. Chuanoi, T. Suma, Y. Anraku, K. Hayashi, M. Naito, H. J. Kim, I. C. Kwon, K. Miyata, A. Kishimura, K. Kataoka, “Self-assembly of siRNA/PEG-b-catiomer at integer molar ratio into 100 nm-sized vesicular polyion complexes (siRNAsomes) for RNAi and codelivery of cargo macromoleculesJournal of the American Chemical Society 141, 3699-3709 (2019).

  15. M. Naito, Y. Otsu, R. Kamegawa, K. Hayashi, S. Uchida, H. J. Kim, K. Miyata, “Tunable non-enzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiencyScience and Technology of Advanced Materials 20, 105-115 (2019).

  16. Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, “Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cellsJournal of Controlled Release 295, 268-277 (2019).

  17. H. J. Kim, Y. Yi, A. Kim, K. Miyata, “Small delivery vehicles of siRNA for enhanced cancer targetingBiomacromolecules 19, 2377-2390 (2018).

  18. H. S. Min*, H. J. Kim*, J. Ahn, M. Naito, K. Hayashi, K. Toh, B. S. Kim, Y. Matsumura, I. C. Kwon, K. Miyata, K. Kataoka, “Tuned density of anti-tissue factor antibody fragment onto siRNA-loaded polyion complex micelles for optimizing targetability into pancreatic cancer cellsBiomacromolecules 19, 2320-2329 (2018). *co-first author.

  19. K. Lee, M. Conboy, H. -M. Park, F. Jiang, H. J. Kim, M. A. Dewitt, V. A. Mackley, K. Chang, A. Rao, C. Skinner, T. Shobha, M. Mehdipour, H. Liu, W.-C. Huang, F. Lan, N. L. Bray, S. Li, J. E. Corn, K. Kataoka, J. A. Doudna, I. Conboy, N. Murthy, “Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repairNature Biomedical Engineering 1, 889-901 (2017).

  20. Y. Zou, M. Zheng, W. Yang, F. Meng, K. Miyata, H. J. Kim, K. Kataoka, Z. Zhong, “Virus-mimicking chimaeric polymersomes boost targeted cancer siRNA therapy in vivoAdvanced Materials 29, 1703285 (2017).

  21. M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka, “Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA deliveryJournal of Biomaterials Science, Polymer Edition 28, 1109-1123 (2017).

  22. K. Katsushima, A. Natsume, F. Ohka, K. Shinjo, A. Hatanaka, N. Ichimura, S. Sato, S. Takahashi, H. Kimura, Y. Totoki, T. Shibata, M. Naito, H. J. Kim, K. Miyata, K. Kataoka, Y. Kondo, “Targeting the Notch-Regulated Non-coding RNA TUG1 for glioma treatmentNature Communications 7, 13616 (2016).

  23. Y. Yi, H. J. Kim, P. Mi, M. Zheng, H. Takemoto, K. Toh, B. -S. Kim, K. Hayashi, M. Naito, Y. Matsumoto, K. Miyata, K. Kataoka, “Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticlesJournal of Controlled Release 244 PartB, 247-256 (2016).

  24. H. J. Kim, A. Kim, K. Miyata, K. Kataoka, “Recent progress in development of siRNA delivery vehicles for cancer therapyAdvanced Drug Delivery Review 104, 61-77 (2016).

  25. H. Nishida, Y. Matsumoto, K. Kawana, R. J. Christie, M. Naito, B. -S. Kim, K. Toh, H. -S. Min, Y. Yi, Y. Matsumoto, H. J. Kim, K. Miyata, A. Taguchi, K. Tomio, A. Yamashita, T. Inoue, H. Nakamura, A. Fujimoto, M. Sato, M. Yoshida, K. Adachi, T. Arimoto, O. Wada-Hiraike, K. Oda, T. Nagamatsu, N. Nishiyama, K. Kataoka, Y. Osuga, T. Fujii, “Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenesJournal of Controlled Release 231, 29-37 (2016).

  26. M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. J. Kim, Y. Miura, J. Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata, K. Kataoka, “siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacyBiomacromolecules 17, 246-255 (2016).

  27. K. Lee, M. Rafi, X. Wang, K. Aran, X. Feng, C. L. Sterzo, R. Tang, N. Lingampalli, H. J. Kim, N. Murthy, “In vivo delivery of transcription factors with multifunctional oligonucleotides” Nature Materials 14, 701-706 (2015).

  28. K. Lee, P. Yu, N. Lingampalli, H. J. Kim, R. Tang, N. Murthy. “Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells” International Journal of Nanomedicine 10, 1841-1854 (2015).

  29. H. J. Kim, H. Takemoto, Y. Yi, M. Zheng, Y. Maeda, H. Chaya, K. Hayashi, P. Mi, F. Pittella, R. J. Christie, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka. “Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold NanoparticlesACS Nano 8, 8979-8991 (2014).

  30. H. J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka. “siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic coreBiomaterials 35, 4548-4556 (2014).

  31. F. Pittella, H. Cabral, Y. Maeda, P. Mi, S. Watanabe, H. J. Kim, N. Nishiyama, K. Miyata, K. Kataoka. “Systemic siRNA delivery to spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelleJournal of Controlled Release 178, 18-24 (2014).

  32. H. J. Kim, T. Ishii, M. Zheng, S. Watanabe, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka. Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancerDrug Delivery and Translational Research 4, 55-60 (2014). *2014 DDTR Outstanding Research Paper Award by Controlled Release Society.

  33. Christie, R. J.,  Matsumoto, Y., Miyata, K., Nomoto, T., Fukushima, S., Osada, K., Halnaut, J., Pittella,F., Kim, H. J., Nishiyama, N., Kataoka, K. “Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injectionACS Nano 6, 5174-5189 (2012).

  34. H. J. Kim, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka, “PEG-Detachable Cationic Polyaspartamide Derivatives Bearing Stearoyl Moieties for Systemic siRNA delivery toward Subcutaneous BxPC3 Pancreatic Tumor” Journal of Drug Targeting 20, 33-42 (2012).

  35. F. Pittella, M. Zhang, Y. Lee, H. J. Kim, T. Tockary, K. Osada, T. Ishii, K. Miyata, N. Nishiyama, K. Kataoka, “Enhanced Endosomal Escape of siRNA-Incorporating Hybrid Nanoparticles from Calcium Phosphate and PEG-Block Charge Conversional Polymer for Efficient Gene Knockdown with Negligible Cytotoxicity” Biomaterials 32, 3106-3114 (2011).

  36. H. J. Kim, A. Ishii, K. Miyata, Y. Lee, S. Wu, N. Nishiyama, K. Kataoka, “Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown” Journal of Controlled Release 145, 141-148 (2010).

  37. Y. Lee, T. Ishii, H. J. Kim, N. Nishiyama, Y. Hayakawa, K. Itaka, K. Kataoka, “Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles” Angew. Chem. Int. Ed. 49, 2552-2555 (2010).

  38. Y. Lee, T. Ishii, H. Cabral, H. J. Kim, J. -H. Seo, N. Nishiyama, H. Oshima, K. Osada, K. Kataoka, "Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm" Angew. Chem. Int. Ed. 48, 5309-5312 (2009).

  39. H. J. Kim, E. Chatani, Y. Goto, and S. R. Paik, “Seed-dependent Accelerated Fibrillation of α-Synuclein Induced by Periodic Ultrasonication Treatment” J. Microbiol. Biotechnol. 17, 2027-2032 (2007).

  40. H. J. Kim, D. Lee, C.-H. Lee, K. C. Chung, J. Kim, and S. R. Paik, "Calpain-resistant fragment(s) of alpha-synuclein regulates the synuclein-cleaving activity of 20S proteasomeArchives of Biochemistry and Biophysics, 455, 40-47 (2006).

  41. I.-H. Lee, H. J. Kim, C.-H. Lee, and S. R. Paik, "Regulation of m-calpain activity by alpha-synuclein and its C-terminal fragment (alpha-syn61-140)Bulletin of the Korean Chemical Society, 27, 1001-1004 (2006).

  42. C.-H. Lee, H. J. Kim, J.-H. Lee, H.-J. Cho, J. Kim, K. C. Chung, S. Jung, and S. R. Paik, "Dequalinium-induced Protofibril Formation of alpha-SynucleinJournal of Biological Chemistry, 281, 3463-3472 (2006).

  43. T. Kang, S. Hong, H. J. Kim, J. Moon, S. Oh, S. R. Paik, and J. Yi, "Characterization of Surface-Confined alpha-Synuclein by Surface Plasmon Resonance MeasurementsLangmuir, 22, 13-17 (2006).

Book Chapter

  1. H. J. Kim, M. Zheng, K. Miyata, K. Kataoka, “Preparation of polyion complex micelles using block copolymers for siRNA delivery”, Methods Mol. Biol. Springer, 1364, 89-103 (2016).

  2. Y. Matsumoto, T. Nomoto, K. Toh, H. Cabral, M. Murakami, R. J. Christie, H. J. Kim, T. Ogura, K. Miyata, N. Nishiyama, T. Yamasoba, K. Kataoka, “Intravital Real-Time Confocal Laser Scanning Microscopy for the In Situ Evaluation of Nanocarriers”, Cancer Targeted Drug Delivery, Springer, 607-620 (2013).